The Martynowycz Lab
About our Lab

Our Research Focus

Structural Biology
Delving into the intricate architecture of biological macromolecules to uncover their functional mechanisms.

Cryo-Electron Microscopy
Utilizing state-of-the-art imaging techniques to visualize molecular structures at near-atomic resolution.

Computational Modeling
Employing advanced computational tools to simulate and predict molecular behaviors and interactions.
Principle Investigator

Mike Martynowycz
Dr. Michael Martynowycz earned his BS in Mathematics and Theoretical Physics from Loyola University Chicago. After a two-year break, he completed an MS in Physics at the Illinois Institute of Technology (IIT), where he served as an NSF Science Education Fellow at the Adler Planetarium and Science Museum. He continued at IIT for his PhD in Physics under the supervision of Dr. David Gidalevitz, specializing in membrane biophysics and X-ray scattering. During this time, he was awarded the Dean’s Fellowship and later worked as a Laboratory Graduate Fellow at Argonne National Laboratory.
Dr. Martynowycz began his postdoctoral training at the Howard Hughes Medical Institute’s Janelia Research Campus in the lab of Dr. Tamir Gonen, focusing on electron microscopy. He subsequently joined the Department of Biological Chemistry at UCLA’s David Geffen School of Medicine, where he expanded his expertise in membrane protein biochemistry and developed innovative methods for determining crystal structures using electron diffraction.
In 2024, Dr. Martynowycz moved to Buffalo to establish his lab at the Hauptman-Woodward Medical Research Institute. He is also a tenure-track Assistant Professor of Structural Biology at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo. His research focuses on advancing electron microscopy techniques, developing novel antibiotic molecules, and elucidating the structures and functions of G Protein-Coupled Receptors.
Postdoctoral Scholar

Purna Vasireddy
Dr. Purna Vasireddy is a synthetic chemist with extensive experience in organic synthesis, peptide and peptoid chemistry, and drug discovery. He earned his PhD in Organic Chemistry from the University of North Dakota, where his research focused on developing novel cyclopalladated complexes and their applications in catalysis and asymmetric synthesis. Dr. Vasireddy brings over a decade of industrial experience, having worked on designing and synthesizing complex molecules for pharmaceutical and biotechnology projects. His expertise includes multi-step organic synthesis, solid- and solution-phase peptide synthesis, and analytical techniques such as NMR, MS, and chromatography. At the Martynowycz Lab, Dr. Vasireddy focuses on developing advanced synthetic methodologies and contributing to the lab’s efforts in structural biology and antimicrobial drug discovery.
Graduate Students

veronica nickerson
Veronica would never steal from another lab.

tim low-beer
This is Tim. He is wearing a cheese sombrero.
lab hound

elsa mcwoofsnoot
Elsa is here for moral support, but will settle for treats.